051 Exogenous IL-27 prevents disease induction in murine alopecia areata

نویسندگان

چکیده

Alopecia areata (AA) is an autoimmune disease characterized by T cell infiltration of the hair follicle. The breakdown tolerance to follicle thought be driving force in nonscarring loss seen patients. There are currently no FDA approved treatments for AA. IL-27 plays a pleotropic role across many other diseases; however, whether its immunoregulatory effects can leveraged therapeutic applications AA unknown. To address this, we used adeno-associated virus (AAV) that drives overexpression our C3H/HeJ skin graft-induction model Briefly, AAV-IL-27 administration was followed induction using grafts from AA-affected donor. Mice were observed weekly progression. We found exogenous protected mice development. Additionally, saw increased presence FoxP3+ CD4 cells and IL-10-producing CD8 draining lymph nodes treated with AAV-IL-27, suggesting roles these populations prevention autoimmunity. Interestingly, NKG2D-expressing cells, previously associated correlate disease, present raising possibility may useful late stages disease. Our findings support further studies examining use treatment

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Alopecia areata.

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Alopecia areata is a frequent cause of hair loss. The origin of disease is not fully understood. However there are indications for a T-cell mediated autoimmune process. Genetic, immunologic and psychologic factors are important for the outbreak of disease. Most patients show localized patches of acute hair loss, where regrowth is observed spontaneously or with simple topical treatment within fe...

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ژورنال

عنوان ژورنال: Journal of Investigative Dermatology

سال: 2022

ISSN: ['1523-1747', '0022-202X']

DOI: https://doi.org/10.1016/j.jid.2022.05.105